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Enhancement of nerve regeneration along a chitosan nanofiber mesh tube on which electrically polarized β-tricalcium phosphate particles are immobilized

Paper ID Volume ID Publish Year Pages File Format Full-Text
1192 78 2010 7 PDF Available
Title
Enhancement of nerve regeneration along a chitosan nanofiber mesh tube on which electrically polarized β-tricalcium phosphate particles are immobilized
Abstract

The ability of β-tricalcium phosphate (β-TCP) particles to store electric charge was confirmed by thermally stimulated depolarization current measurement as well as surface potential measurement. The efficacy of stored electrical charge on β-TCP particles in enhancing nerve regeneration was evaluated. Bridge grafting was performed into sciatic nerve defects in Wistar rats with the following tubes: chitosan mesh tubes; chitosan mesh tubes on which β-TCP particles with or without electrical polarization treatment had been immobilized (polarized and non-polarized tubes, respectively). As a control, isografts were used. Both motor and sensory nerve function as well as electrophysiological recovery progressed with time in each group. Immunofluorescence revealed rapider nerve regeneration in the polarized tube group compared with the non-polarized tube group. The axon density and axon area in the polarized tube group were significantly greater than those in the chitosan mesh tube and non-polarized group, and showed no significant differences from the control group. These results suggest that the stored charge on electrically polarized β-TCP particles immobilized on chitosan mesh tubes may enhance nerve regeneration to the same extent as isografting.

Keywords
Tissue regeneration; Nerve conduit; Chitosan; β-Tricalcium phosphate; Electrical polarization
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Enhancement of nerve regeneration along a chitosan nanofiber mesh tube on which electrically polarized β-tricalcium phosphate particles are immobilized
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 6, Issue 10, October 2010, Pages 4027–4033
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us