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The self-setting properties and in vitro bioactivity of tricalcium silicate

Paper ID Volume ID Publish Year Pages File Format Full-Text
11926 767 2005 9 PDF Available
Title
The self-setting properties and in vitro bioactivity of tricalcium silicate
Abstract

In this study, tricalcium silicate (Ca3SiO5), as a new promising injectable bioactive material, was employed to investigate its physical and chemical properties for an injectable bioactive cement filler. The workable Ca3SiO5 pastes with a liquid to powder (L/P) ratio of 0.8–1.2 ml g−1could be injected for 15–60 min (nozzle diameter 2.0 mm). The setting process yielded cellular structures with compressive strength of 6.4–20.2 MPa after 2–28 days. The in vitro bioactivity of Ca3SiO5 paste was investigated by soaking in simulated body fluid (SBF) for various periods. The result showed that the Ca3SiO5 paste could induce hydroxyapatite (HA) formation and dissolve slowly in SBF. The result of indirect cytotoxicity evaluation indicated that Ca3SiO5 paste had a stimulatory effect on cell growth in a certain concentration range. The exothermic process showed that Ca3SiO5 had lower heat evolution rate during the hydration as compared to calcium phosphate cement (CPC). Our results indicated that Ca3SiO5 paste was bioactive and dissolvable, and it is a progressive candidate for further investigation as injectable tissue repairing substitute.

Keywords
Tricalcium silicate; Injectability; Self-setting; Bioactivity; Cell proliferation
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 26, Issue 31, November 2005, Pages 6113–6121
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us