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Characterization and biocompatibility of organogels based on l-alanine for parenteral drug delivery implants

Paper ID Volume ID Publish Year Pages File Format Full-Text
11941 767 2005 12 PDF Available
Title
Characterization and biocompatibility of organogels based on l-alanine for parenteral drug delivery implants
Abstract

The development of simple and efficient drug delivery systems for the sustained release of peptides/proteins and low molecular weight hydrophilic molecules is an ongoing challenge. The purpose of this work was to prepare and characterize novel biodegradable in situ-forming implants obtained via the self-assembly of l-alanine derivatives in pharmaceutical oils. Six different amphiphilic organogelators based on l-alanine were synthesized. These derivatives could successfully gel various vegetable and synthetic oils approved for parenteral administration. Gelation was thermoreversible, and phase transition temperatures depended on gelator structure, concentration and solvent. Hydrogen bonds and van der Waals interactions were shown to be the main forces implicated in network formation. Selected formulations were then injected subcutaneously in rats for preliminary assessment of biocompatibility. Histopathological analysis of the surrounding tissues revealed mild, chronic inflammation and an overall good biocompatibility profile of the implants over the 8 wk evaluation period. This study demonstrates that in situ-forming organogels represent a potentially promising platform for sustained drug delivery.

Keywords
In situ-forming implant; Biocompatibility; Controlled drug release; Organogel
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Characterization and biocompatibility of organogels based on l-alanine for parenteral drug delivery implants
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 26, Issue 31, November 2005, Pages 6242–6253
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us