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Biocatalytic synthesis of highly ordered degradable dextran-based hydrogels

Paper ID Volume ID Publish Year Pages File Format Full-Text
11945 769 2005 10 PDF Available
Title
Biocatalytic synthesis of highly ordered degradable dextran-based hydrogels
Abstract

We have prepared unique macroporous and ordered dextran-based hydrogels using a single-step biocatalytic transesterification reaction between dextran and divinyladipate in neat dimethylsulfoxide. These hydrogels show a unimodal distribution of interconnected pores with average diameters from 0.4 to 2.0 μm depending on the degree of substitution. In addition, the hydrogels show a higher elastic modulus for a given swelling ratio than chemically synthesized dextran-based hydrogels. In vivo studies in rats show that the hydrogel networks are degradable over a range of time scales from 5 to over 40 days, and possess good biocompatibility, as reflected in only a mild inflammatory reaction and minor fibrous capsule formation during the time-frame of subcutaneous implantation. These combined properties may offer competitive advantages in biomedical applications ranging from tissue engineering to controlled drug delivery.

Keywords
Enzyme; Dextran; Hydrogel; Cross-linking; Biodegradation
First Page Preview
Biocatalytic synthesis of highly ordered degradable dextran-based hydrogels
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 26, Issue 23, August 2005, Pages 4707–4716
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering