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Parameters influencing the stealthiness of colloidal drug delivery systems

Paper ID Volume ID Publish Year Pages File Format Full-Text
11977 770 2006 18 PDF Available
Title
Parameters influencing the stealthiness of colloidal drug delivery systems
Abstract

Over the last few decades, colloidal drug delivery systems (CDDS) such as nano-structures have been developed in order to improve the efficiency and the specificity of drug action. Their small size permits them to be injected intravenously in order to reach target tissues. However, it is known that they can be rapidly removed from blood circulation by the immune system. CDDS are removed via the complement system and via the cells of the mononuclear phagocyte system (MPS), after their recognition by opsonins and/or receptors present at the cell surface. This recognition is dependent on the physicochemical characteristics of the CDDS. In this study, we will focus on parameters influencing the interactions of opsonins and the macrophage plasma membrane with the surface of CDDS, whereby parameters of the polymer coating become necessary to provide good protection.

Keywords
Complement; Liposome; Macrophage; Nanoparticle; Polyethylene oxide; Protein adsorptionAP, alternative pathway; CDDS, colloidal drug delivery systems; CP, classical pathway; CRP, C-reactive protein; DLVO, Derjaguin–Landau–Verwey–Overbeek; LDL, low-density
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 27, Issue 24, August 2006, Pages 4356–4373
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us