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The effect of ε-caproyl/d,l-lactyl unit composition on the hydrolytic degradation of poly(d,l-lactide-ran-ε-caprolactone)-poly(ethylene glycol)-poly(d,l-lactide-ran-ε-caprolactone)

Paper ID Volume ID Publish Year Pages File Format Full-Text
11983 771 2006 9 PDF Available
Title
The effect of ε-caproyl/d,l-lactyl unit composition on the hydrolytic degradation of poly(d,l-lactide-ran-ε-caprolactone)-poly(ethylene glycol)-poly(d,l-lactide-ran-ε-caprolactone)
Abstract

The degradation of P(DLAX-ran-CLY)-b-PEG-b-P(DLAX-ran-CLY)s ( P(DLAX-ran-CLY): Poly(d,l-lactide-ran-ε-caprolactone), PEG: Poly(ethylene glycol), X: d,l-lactyl unit fraction, Y: ε-caproyl unit fraction) is investigated. The fraction of DLA in the both end blocks is varied while the overall molecular weight and molecular weight of PEG are kept constant. DSC, XRD and GPC are employed to track the degradation process up to 200 days. Also the change in the surface and cross-sectional morphology is provided by SEM micro-photographs. The result of water absorption and weight loss characterization reveals that the incorporation of DLA in the polyester block could be an effective tool to facilitate degradation as well as water absorption. By tracking the change of molecular weight and polydispersity, chain scission and transport or removal of degraded product from the specimen were found to play a complex role in overall degradation.

Keywords
Poly(d,l-lactide-ran-ε-caprolactone)-b-poly(ethylene glycol)-b-poly(d,l-lactide-ran-ε-caprolactone); Triblock copolymer; Degradation; Crystallinity; Morphology
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The effect of ε-caproyl/d,l-lactyl unit composition on the hydrolytic degradation of poly(d,l-lactide-ran-ε-caprolactone)-poly(ethylene glycol)-poly(d,l-lactide-ran-ε-caprolactone)
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 27, Issue 4, February 2006, Pages 544–552
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us