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Analytically derived material properties of multilaminated extracellular matrix devices using the ball-burst test

Paper ID Volume ID Publish Year Pages File Format Full-Text
12007 772 2005 14 PDF Available
Title
Analytically derived material properties of multilaminated extracellular matrix devices using the ball-burst test
Abstract

Xenogeneic extracellular matrices (ECMs) have been shown to be effective as naturally occurring scaffolds for soft-tissue repair. As acellular tissue substitutes at the time of surgical implantation, ECMs are subjected to the mechanical forces and micro-environmental conditions representative of the anatomical location in which they are placed. Ideally such natural scaffolds would possess mechanical properties that allow for normal tissue function in and around the implant site. The ball-burst test was used to simulate biaxial forces and to determine the strength of the ECM scaffold under a relevant physiological loading condition. The ball-burst test, in itself, does not quantify intrinsic mechanical properties and therefore a methodology was developed to determine the maximum stress resultant tangent modulus (MSRTM) or the maximum stress tangent modulus (MSTM), stress to failure (σf)(σf), failure stress resultant (Nf)(Nf),   ball-burst pressure (P)(P), and maximum elongation (λmax)(λmax) from the raw ball-burst data obtained at a constant-rate of transverse. The analytical methodology was compared to finite element simulations and showed good correlation with the analytical solution presented. The proposed approximations were used to compute biaxial failure properties for a variety of multilaminate ECM devices with varying number of layers, disinfection and sterilization, and organ origin.

Keywords
Bladder; ECM; Multilaminate devices; Mechanical properties; Mechanical test; Ball-burst test; Scaffold
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Analytically derived material properties of multilaminated extracellular matrix devices using the ball-burst test
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 26, Issue 27, September 2005, Pages 5518–5531
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us