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Diffusion in three-dimensionally ordered scaffolds with inverted colloidal crystal geometry

Paper ID Volume ID Publish Year Pages File Format Full-Text
12014 772 2005 5 PDF Available
Title
Diffusion in three-dimensionally ordered scaffolds with inverted colloidal crystal geometry
Abstract

Inverted colloidal crystal geometry has been recently utilized in the design of highly organized 3D cell scaffolds. The regularity of the resulting scaffolds enables computational modeling of scaffold properties. In this work we probe the resistance offered by these scaffolds to nutrient transport, by using Brownian dynamics and Monte Carlo simulations to model the effective nutrient diffusivity. Brownian dynamics simulations indicate that the effective diffusivity for small nutrients in the scaffold, Deff=0.3D0Deff=0.3D0, where D0D0 is the free solution diffusivity. Further, results of Monte Carlo simulations for dilute solutions of larger particles show that the DeffDeff decreases linearly with the size of the particles.

Keywords
Three-dimensional cell scaffolds; Inverted colloidal crystals; Diffusion modeling; Brownian dynamics; Cell culture optimization
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Diffusion in three-dimensionally ordered scaffolds with inverted colloidal crystal geometry
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 26, Issue 27, September 2005, Pages 5581–5585
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us