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Chitin/PLGA blend microspheres as a biodegradable drug delivery system: a new delivery system for protein

Paper ID Volume ID Publish Year Pages File Format Full-Text
12030 773 2003 14 PDF Available
Title
Chitin/PLGA blend microspheres as a biodegradable drug delivery system: a new delivery system for protein
Abstract

Novel chitin/PLGAs and chitin/PLA based microspheres were developed for the delivery of protein. These biodegradable microspheres were prepared by polymers blending and wet phase-inversion methods. The parameters such as selected non-solvents, temperature of water and ratio of polylactide to polyglycolide were adjusted to improve thermodynamic compatibility of individual polymer (chitin and PLGAs or chitin/PLA), which affects the hydration and degradation properties of the blend microspheres. Triphasic pattern of drug release model is observed from the release of protein from the chitin/PLGAs and chitin/PLA microspheres: the initially fast release (the first phase), the following slow release (the second phase) and the second burst release (the third phase). Formulations of the blends, which are based on the balance among the hydration rate of the chitin phase and degradation of chitin/PLA and PLGA phase, can lead to a controllable release of bovine serum albumin (BSA). In conclusion, such a chitin/PLGA 50/50 microsphere is novel and interesting, and may be used as a protein delivery system.

Keywords
Chitin; PLGA 50/50; Biodegradable; Microsphere; Phase separation; Drug delivery
First Page Preview
Chitin/PLGA blend microspheres as a biodegradable drug delivery system: a new delivery system for protein
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 24, Issue 27, December 2003, Pages 5023–5036
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering