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In vivo conjunctival reconstruction using modified PLGA grafts for decreased scar formation and contraction

Paper ID Volume ID Publish Year Pages File Format Full-Text
12033 773 2003 11 PDF Available
Title
In vivo conjunctival reconstruction using modified PLGA grafts for decreased scar formation and contraction
Abstract

The in vivo reconstruction of conjunctiva was investigated by using modified poly(lactide-co-glycolide) (PLGA) 50/50 scaffolds. The porous PLGA matrices were prepared by a solvent-casting particulate-leaching method with NaCl, then modified with collagen, hyaluronic acid (HA) or/and human amniotic membrane (AM) component. The growth of corneal epithelial cells and human stromal fibroblasts on the scaffolds was investigated in vitro. All the modified PLGA scaffolds demonstrated enhanced cell adhesion and proliferation as compared to PLGA untreated, and the number of cells proliferated after 1 week was increased in the order of PLGA

Keywords
Conjunctival reconstruction; Modified PLGA graft; Low contraction and scar; Rabbit model
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In vivo conjunctival reconstruction using modified PLGA grafts for decreased scar formation and contraction
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 24, Issue 27, December 2003, Pages 5049–5059
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us