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Intraperitoneal stability of alginate–polyornithine microcapsules in rats: An FTIR and SEM analysis

Paper ID Volume ID Publish Year Pages File Format Full-Text
12043 775 2006 10 PDF Available
Title
Intraperitoneal stability of alginate–polyornithine microcapsules in rats: An FTIR and SEM analysis
Abstract

Alginate–polycation microcapsule systems have been used over decades as delivery vehicles for cell and protein therapy. These systems have been unpredictable across a range of indications with questions resulting around the inherent stability of the alginate polysaccharide and failure mode of the delivery system. The current study focuses on such a system using 5 different alginates, 2 of which are commercially purified, which are crosslinked by polyornithine. Capsules formed by frequency-generated droplet formation were studied in the peritoneal cavity of Long-Evans rats over the course of 3 months by morphometry, Fourier-transform infrared spectroscopy (FTIR), and scanning electron microscopy of the surface. Individual capsule components were also investigated on FTIR and a relative stability index was generated by titration for comparison to explanted samples over time. Using these techniques, a distinct degradation pattern was noted and is compared between the 5 alginate sources.

Keywords
Alginate; Biodegradation; Cell encapsulation; FTIR; Hydrogel; SEM
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Intraperitoneal stability of alginate–polyornithine microcapsules in rats: An FTIR and SEM analysis
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 27, Issue 19, July 2006, Pages 3570–3579
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us