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The fibroblast response to tubes exhibiting internal nanotopography

Paper ID Volume ID Publish Year Pages File Format Full-Text
12067 776 2005 8 PDF Available
Title
The fibroblast response to tubes exhibiting internal nanotopography
Abstract

The use of three-dimensional scaffolds in cell and tissue engineering is widespread; however, the use of such scaffolds, which bear additional cellular cues such as nanotopography, is as yet in its infancy. This paper details the novel fabrication of nylon tubes bearing nanotopography via polymer demixing, and reports that the topography greatly influenced fibroblast adhesion, spreading, morphology and cytoskeletal organisation. The use of such frameworks that convey both the correct mechanical support for tissue formation and stimulate cells through topographical cues may pave the way for future production of intelligent materials and scaffolds.

Keywords
Actin; Cell adhesion; Cell morphology; Cell spreading; Nanotopography; Vinculin
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The fibroblast response to tubes exhibiting internal nanotopography
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 26, Issue 24, August 2005, Pages 4985–4992
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us