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Bovine BMP osteoinductive potential enhanced by functionalized dextran-derived hydrogels

Paper ID Volume ID Publish Year Pages File Format Full-Text
12077 776 2005 8 PDF Available
Title
Bovine BMP osteoinductive potential enhanced by functionalized dextran-derived hydrogels
Abstract

This study evaluated functionalized dextran-derived hydrogels as BMP carriers using both in vitro and in vivo models. In vitro release kinetics indicated that dextran-derived hydrogels could retain rhBMP-2 growth factor in a variable manner depending on their functionalization ratio. The potential of these hydrogels when combined with extracted bovine BMP to enhance the bone formation was evaluated in a rat ectopic model. The largest osteoinduction was found when using hydrogels exhibiting the highest growth factor retention capacity. In addition, some implanted hydrogels demonstrated a capacity to induce an in-vivo calcification certainly related to their chemical composition. These properties make these materials interesting osteoconductive BMP carriers, allowing to decrease the amount of implanted factor required for bone regeneration.

Keywords
Hydrogel; Functionalized dextran; Bmp delivery system; Osteoinduction; Ectopic site
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Bovine BMP osteoinductive potential enhanced by functionalized dextran-derived hydrogels
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 26, Issue 24, August 2005, Pages 5085–5092
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us