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In vitro behavior of osteoblast-like cells on fluoridated hydroxyapatite coatings

Paper ID Volume ID Publish Year Pages File Format Full-Text
12083 777 2005 8 PDF Available
Title
In vitro behavior of osteoblast-like cells on fluoridated hydroxyapatite coatings
Abstract

In this work, fluoridated hydroxyapatite (Ca10(PO4)6Fx(OH)2−x or FHA) coatings are prepared by sol–gel method for study of the influence of F content on the behavior of osteoblast-like cells. The results show that the cells well attach and proliferate on the FHA coatings studied (Ca10(PO4)6F0.67–2.00(OH)0–1.33). With increasing F content in the FHA coatings, percentage of cell in S period increases, indicating F in the coating favors the proliferation process of the cells. On the other hand, the proliferation rate increases inversely with zeta potential of the coating surface. As tested from the MTT of the cells cultured in the leaching out solution, increase of F content in the FHA coatings results in a slight decrease in cell proliferation rate, which is most probably due to reduction in release of Ca2+ ions. As a compromise among cell attachment, cell proliferation, apatite deposition and ability to resist dissolution, it is suggested that FHA coatings (Ca10(PO4)6Fx(OH)2−x) with x in the range of 0.67–1.48, from the results of this study, may be most suitable for real case implantation.

Keywords
Fluoridated hydroxyapatite; Surface fluorine content; Osteoblast-like cells
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In vitro behavior of osteoblast-like cells on fluoridated hydroxyapatite coatings
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 26, Issue 32, November 2005, Pages 6288–6295
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us