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A poly(lactic acid)/calcium metaphosphate composite for bone tissue engineering

Paper ID Volume ID Publish Year Pages File Format Full-Text
12086 777 2005 9 PDF Available
Title
A poly(lactic acid)/calcium metaphosphate composite for bone tissue engineering
Abstract

A new method to prepare PLA/CMP (poly-l-lactide/calcium metaphosphate) composite scaffolds was developed for effective bone tissue engineering. This novel sintering method is composed of pressing the mixture of PLA, CMP, and salt particles at 150 MPa for 3 min followed by heat treatment at 210 °C for 30 min. The scaffolds had a homogeneously interconnected porous structure without a skin layer, and they exhibited a narrower pore size distribution and higher mechanical strength in comparison with scaffolds made by a solvent casting method. The scaffolds were seeded by osteoblasts and cultured in vitro or implanted into nude mice subcutaneously for up to 5 weeks. The number of cells attached to and proliferated on the scaffolds at both in vitro and in vivo was in the order of; PLA by novel sintering

Keywords
Bone regeneration; Tissue engineering; Composites; Poly-l-lactide; Calcium metaphosphate
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A poly(lactic acid)/calcium metaphosphate composite for bone tissue engineering
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 26, Issue 32, November 2005, Pages 6314–6322
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us