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Modulation of the pH-responsive properties of poly(l-lysine iso-phthalamide) grafted with a poly(ethylene glycol) analogue

Paper ID Volume ID Publish Year Pages File Format Full-Text
12090 777 2005 10 PDF Available
Title
Modulation of the pH-responsive properties of poly(l-lysine iso-phthalamide) grafted with a poly(ethylene glycol) analogue
Abstract

A pH responsive pseudopeptide, poly(l-lysine iso-phthalamide), has been modified with a hydrophilic poly(ethylene glycol) analogue, Jeffamine M-1000® and the effect of grafting ratio on the pH responsive behaviour of the grafted polymers in aqueous solution investigated using fluorescence and 1H NMR spectroscopy. It was demonstrated that at below 35.1 wt% grafting, the modified polymers retained the pH-driven conformational transition of the parent polymer from an expanded structure at high degrees of ionisation to a compact hydrophobically stabilised structure at low degrees of ionisation. The onset of pH response and the pH range over which the conformational transition occurred varied significantly with degree of grafting. At Jeffamine M-1000® ratios in excess of 48.0 wt%, the graft polymer existed in a micellular form over the whole pH studied. Potential applications in drug delivery of both the linear and micellular forms are discussed.

Keywords
Peptide; Polyethylene oxide; Hydrophilicity; Fluorescence; Drug delivery
First Page Preview
Modulation of the pH-responsive properties of poly(l-lysine iso-phthalamide) grafted with a poly(ethylene glycol) analogue
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 26, Issue 32, November 2005, Pages 6357–6366
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering