fulltext.study @t Gmail

Synthesis, properties and controlled release behaviors of hydrogel networks using cyclodextrin as pendant groups

Paper ID Volume ID Publish Year Pages File Format Full-Text
12091 777 2005 8 PDF Available
Title
Synthesis, properties and controlled release behaviors of hydrogel networks using cyclodextrin as pendant groups
Abstract

Based on inclusion character of β-cyclodextrin (β-CD) with drug molecule and low glass transition temperature of poly(2-hydroxyethyl acrylate) (PHEA), a series of hydrogels with different compositions were synthesized by the copolymerization of a monovinyl cyclodexrin monomer with 2-hydroxyethyl acrylate (HEA). The structure and properties of the hydrogels were characterized by FTIR, DSC, TGA and swelling measurements. It is found that swelling ratios of these β-CD hydrogels can keep a relative stability in the range of pH from 1.4 to 7.4, and are not sensitive to change in NaCl concentration. Using drug N-acety-5-methoxytryptamine (melatonin, MEL) as a model molecule, the controlled drug release behaviors of these hydrogels were investigated. The results indicate that the diffusion and permeation of MEL from the hydrogels may be a dominant factor for its release. Owing to the formation of MEL/β-CD retarding diffusion rate of MEL, a sustained release of MEL from hydrogel with high content of β-CD can be obtained compared with hydrogel PHEA without β-CD.

Keywords
Hydrogel; Cyclodextrin; Inclusion complex; The controlled release
First Page Preview
Synthesis, properties and controlled release behaviors of hydrogel networks using cyclodextrin as pendant groups
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 26, Issue 32, November 2005, Pages 6367–6374
Authors
, ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us