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Constructing thromboresistant surface on biomedical stainless steel via layer-by-layer deposition anticoagulant

Paper ID Volume ID Publish Year Pages File Format Full-Text
12129 779 2003 7 PDF Available
Title
Constructing thromboresistant surface on biomedical stainless steel via layer-by-layer deposition anticoagulant
Abstract

Multilayer films consisting of polyethylenimine (PEI) and heparin were successfully prepared on biomedical 316L stainless steel surface via electrostatic self-assembly (ESA) of the PEI and heparin. The process of ESA of PEI/heparin was monitored by static contact angle, electrochemical impedance spectroscopy (EIS), reflection adsorption spectroscopy and X-ray photoelectron spectroscopy data. The contact angle and EIS data revealed that the multilayer coating was stable in Tris-HCl (pH 7.35) buffer solution for 21 days. The static platelet adhesion and static clotting time experiments indicated that the PEI/heparin-deposited stainless steel could resist the platelet adhesion and prolong the static clotting time effectively. Such an easy processing and shape-independent method may have good potential for surface modification of cardiovascular devices.

Keywords
Layer-by-layer; Blood-compatibility; 316L stainless steel; Coating
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Constructing thromboresistant surface on biomedical stainless steel via layer-by-layer deposition anticoagulant
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 24, Issue 25, November 2003, Pages 4699–4705
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us