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Cytotoxicity of three-dimensionally ordered macroporous sol–gel bioactive glass (3DOM-BG) ☆

Paper ID Volume ID Publish Year Pages File Format Full-Text
12136 781 2005 8 PDF Available
Title
Cytotoxicity of three-dimensionally ordered macroporous sol–gel bioactive glass (3DOM-BG) ☆
Abstract

In this study, 80% SiO2–20% CaO (mole fraction) three-dimensionally ordered macroporous sol–gel bioactive glass (3DOM-BG, average pore size: 345 nm) particles were prepared and characterized. Since the 3DOM-BGs have a novel microstructure and ion-releasing profile, the cytotoxicity of 3DOM-BG particles was tested. The cytotoxicity tests were performed using MC3T3-E1 osteoblast-like cells: (1) Wst-1 assay for cell viability after culture in extracts from 3DOM-BG particles; (2) phase contrast microscopy for cell morphology after culture with 3DOM-BG particles; and (3) fluorescence microscopy for imaging cells cultured directly on 3DOM-BG particles. The results showed that 3DOM-BG particles were not cytotoxic, and that cells attached, spread and proliferated on and around 3DOM-BG particles.

Keywords
Porosity; Sol–gel; Bioactive glass; Apatite; Cell culture
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Cytotoxicity of three-dimensionally ordered macroporous sol–gel bioactive glass (3DOM-BG) ☆
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 26, Issue 22, August 2005, Pages 4532–4539
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us