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3D femtosecond laser patterning of collagen for directed cell attachment

Paper ID Volume ID Publish Year Pages File Format Full-Text
12143 781 2005 9 PDF Available
Title
3D femtosecond laser patterning of collagen for directed cell attachment
Abstract

Three-dimensional micropatterned collagen scaffolds were fabricated by femtosecond laser ablation. An 800 nm, 45 fs Ti:Sapphire laser was used to create various 3D patterns in a collagen gel, including holes, lines and grids. An optimal collagen concentration was found for both substrate patterning and cell compatibility. The threshold fluence for ablation of the scaffold was found to be 0.06 J/cm2, and the morphology of the ablation craters was measured as a function of fluence. Mesenchymal stem cells from rat bone marrow and human fibroblasts were seeded within the ablated patterns and were shown to be viable for at least 10 days.

Keywords
Cell adhesion; Collagen; Laser ablation; Micropatterning; Tissue engineering
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3D femtosecond laser patterning of collagen for directed cell attachment
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 26, Issue 22, August 2005, Pages 4597–4605
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us