fulltext.study @t Gmail

Antifouling blood purification membrane composed of cellulose acetate and phospholipid polymer

Paper ID Volume ID Publish Year Pages File Format Full-Text
12160 782 2003 10 PDF Available
Title
Antifouling blood purification membrane composed of cellulose acetate and phospholipid polymer
Abstract

The ideal surface of an artificial blood purification membrane needs hemocompatibility and durability of high performance; it should not adsorb any proteins or cells but should still have high permeability in the desired range of solute size. To improve the anti-fouling property of cellulose acetate (CA) membranes, a CA membrane blended with poly(2-methacryloyloxyethyl phosphorylcholine (MPC)-co-n-butyl methacrylate (BMA)) (PMB30) was designed as a blood purification membrane. The polymer solutions for preparing the membrane were prepared using a solvent mixture composed of N, N-dimethylformamide, acetone, 2-propanol or water. The CA and CA/PMB30 blend membranes with an asymmetric and porous structure were prepared by a phase inversion process.The characteristics of the CA/PMB30 blend membrane, such as structural properties, mechanical properties, and solute permeability were examined with attention to changes in the preparation conditions of the membrane. The CA/PMB30 blend membrane had good water and solute permeability and a sharp molecular weight cut-off property. Moreover, the amount of proteins adsorbed on the CA/PMB30 blend membrane surface was less than that of the original CA membrane and a conventional polysulfone membrane. Adhesion and activation of platelets on the CA/PMB30 blend membrane were reduced compared with that on a CA membrane. In addition, the CA/PMB30 blend membrane showed good permselectivity and an antifouling property during a long time ultrafiltration experiment with protein solutions.

Keywords
Cellulose acetate membrane; MPC copolymer; Blood purification; Permeability; Hemocompatibility; Membrane fouling
First Page Preview
Antifouling blood purification membrane composed of cellulose acetate and phospholipid polymer
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 24, Issue 23, October 2003, Pages 4143–4152
Authors
, , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering