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Characterization of heparin surfaces using photoelectron spectroscopy and quartz crystal microbalance

Paper ID Volume ID Publish Year Pages File Format Full-Text
12161 782 2003 7 PDF Available
Title
Characterization of heparin surfaces using photoelectron spectroscopy and quartz crystal microbalance
Abstract

In order to gain insight into the molecular structure of a new heparin surface (Corline heparin surface, CHS), quartz crystal microbalance dissipation (QCM-D) and photoelectron spectroscopy (PES) were used. Two surfaces, with different surface thickness and surface concentration of heparin, were compared. QCM-D measurements provided information on the thickness of the two different heparin surfaces and confirmed that the process of formation of the two layers were virtually identical. PES showed that the thicker coating resulted in complete coverage of the substrate, whereas with the thinner coating Fe signals originating from the stainless steel substrate could be detected. Information of the molecular surface structure of the heparin coatings could be derived from the ratios at different photon energies between S2p signals from sulfonate groups in heparin and disulfide groups originating from a cross-linking unit in the heparin conjugate.

Keywords
Biocompatibility; Photoelectron spectroscopy; QCM-D; Immobilized heparin; Surface characterization
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Characterization of heparin surfaces using photoelectron spectroscopy and quartz crystal microbalance
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 24, Issue 23, October 2003, Pages 4153–4159
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
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Any Questions? feel free to contact us