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Pharmacological characterization of micropatterned cardiac myocytes

Paper ID Volume ID Publish Year Pages File Format Full-Text
12171 782 2003 6 PDF Available
Title
Pharmacological characterization of micropatterned cardiac myocytes
Abstract

The cardiac myocytes patterned on a single cell level were prepared by microcontact printing, and the response to chemical stimuli was studied using confocal fluorescent Ca2+ imaging. The patterned myocytes were found to conjugate by forming gap junction. It was confirmed for the patterned myocytes that gap junction communication was reversibly inhibited by 1-octanol, but activated by caffeine. Localized stimulation with chemicals was also attempted using a microinjection system for the myocyte patterns formed by single cell alignment. This research was carried out with the objective of developing a bioassay system based on a cellular network.

Keywords
Micropatterning; Cardiomyocyte; Cell adhesion; Polydimethylsiloxane; Fibronectin
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Pharmacological characterization of micropatterned cardiac myocytes
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 24, Issue 23, October 2003, Pages 4239–4244
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us