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Fiber templating of poly(2-hydroxyethyl methacrylate) for neural tissue engineering

Paper ID Volume ID Publish Year Pages File Format Full-Text
12174 782 2003 8 PDF Available
Title
Fiber templating of poly(2-hydroxyethyl methacrylate) for neural tissue engineering
Abstract

We have developed a method to create longitudinally oriented channels within poly(2-hydroxyethyl methacrylate) (pHEMA) hydrogels for neural tissue engineering applications. Incorporated into an entubulation strategy, these scaffolds have the potential to enhance nerve regeneration after transection injuries of either the spinal cord or the peripheral nerve by increasing the available surface area and providing guidance to extending axons and invading cells. The fabrication process is straightforward and the resultant scaffolds are highly reproducible. Polycaprolactone (PCL) fibers were extruded and embedded in transparent, crosslinked pHEMA gels. Sonication of the pHEMA/PCL composite in acetone resulted in the complete dissolution of the PCL, leaving longitudinally oriented, fiber-free channels in the pHEMA gel. Regulating the size and quantity of the PCL fibers allowed us to control the diameter and number of channels. Small and large channel scaffolds were fabricated and thoroughly characterized. The small channel scaffolds had 142±7 channels, with approximately 75% of the channels in the 100–200 μm size range. The large channel scaffolds had 37±1 channels, with approximately 77% of the channels in the 300–400 μm range. The equilibrium water content (EWC), porosity and compressive modulus were measured for each of the structures. Small and large channel scaffolds had, respectively, EWCs of 55.0±1.2% and 56.2±2.9%, porosities of 35±1% and 40±1% and compressive moduli of 191±7 and 182±4 kPa.

Keywords
pHEMA; Polycaprolactone; Fibers; Spinal cord injury; Regeneration; Nerve guidance channel; Scaffold; Orientation; Hydrogel
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Fiber templating of poly(2-hydroxyethyl methacrylate) for neural tissue engineering
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 24, Issue 23, October 2003, Pages 4265–4272
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us