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Physico-chemical stability of colloidal lipid particles

Paper ID Volume ID Publish Year Pages File Format Full-Text
12176 782 2003 18 PDF Available
Title
Physico-chemical stability of colloidal lipid particles
Abstract

Recent advances in nanoparticle systems for improved drug delivery display a great potential for the administration of active molecules. Generally, the lipid systems presented the advantage of their low toxicity due to their composition of physiological lipids compared to polymeric particles. The physico-chemical stability of the lipid carriers showed variations due to their numerous compositions and structures. This review consequently focuses on the physico-chemical stability of dispersions in the nanometer range where the lipids are the main or the only components. It highlights on the destabilization mechanisms, the techniques used to detect this destabilization and the inductors of the destabilization. Finally, the methods used to optimize the stability of lipid nanoparticle systems are described in the last part.

Keywords
Review; Physico-chemical stability; Lipid; Drug delivery systems; NanoparticlesBSA, Bovine serum albumin; CETP, Plasma cholesteryl ester transfer protein; DMPG, Dimyristoylphosphatidylglycerol; DOPC, Dioleoylphosphatidylcholine; DOPE, Dioleoylphosphatidyl
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Physico-chemical stability of colloidal lipid particles
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 24, Issue 23, October 2003, Pages 4283–4300
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us