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Biodegradable hydrogels obtained by photocrosslinking of dextran and polyaspartamide derivatives

Paper ID Volume ID Publish Year Pages File Format Full-Text
12177 782 2003 13 PDF Available
Title
Biodegradable hydrogels obtained by photocrosslinking of dextran and polyaspartamide derivatives
Abstract

The functionalization of dextran with glycidyl methacrylate (GMA) leads to the formation of a derivative that generates hydrogels for irradiation at 365 nm. The effects of various polymer concentrations and irradiation times on the yield and the properties of the obtained hydrogels are reported. The networks have been characterized by FT-IR spectra, dimensional analysis and swelling measurements carried out at different pH values. In vitro studies suggest that all samples undergo a partial chemical hydrolysis, whereas the incubation with dextranases causes a total degradation whose rate depends on the degree of crosslinking. In addition, aqueous solutions of functionalized dextran have been irradiated in the presence of PHG (PHEA-GMA), i.e. the copolymer obtained by the reaction of α,β-poly(N-2-hydroxyethyl)-dl-aspartamide (PHEA) with GMA. The crosslinking reaction leads to the formation of new networks containing both polymers whose properties have been investigated. To evaluate the processes which occur during UV irradiation, the sol fractions have been purified and characterized by FT-IR and 1H-NMR analyses. Finally, the suitability of hydrogels deriving from functionalized dextran, crosslinked alone or in the presence of PHG, for drug delivery systems has been investigated choosing theophylline as a model drug.

Keywords
Dextran; α,β-Poly(N-2-hydroxyethyl)-dl-aspartamide; Glycidyl methacrylate; Photocrosslinking; Drug release
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Biodegradable hydrogels obtained by photocrosslinking of dextran and polyaspartamide derivatives
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 24, Issue 23, October 2003, Pages 4301–4313
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
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