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Study of nanoscale structures in hydrated biomaterials using small-angle neutron scattering

Paper ID Volume ID Publish Year Pages File Format Full-Text
1218 79 2012 10 PDF Available
Title
Study of nanoscale structures in hydrated biomaterials using small-angle neutron scattering
Abstract

Distribution of water in three classes of biomedically relevant and degradable polymers was investigated using small-angle neutron scattering. In semicrystalline polymers, such as poly(lactic acid) and poly(glycolic acid), water was found to diffuse preferentially into the non-crystalline regions. In amorphous polymers, such as poly(d,l-lactic acid) and poly(lactic-co-glycolic acid), the scattering after 7 days of incubation was attributed to water in microvoids that form following the hydrolytic degradation of the polymer. In amorphous copolymers containing hydrophobic segments (desaminotyrosyl-tyrosine ethyl ester) and hydrophilic blocks (poly(ethylene glycol) (PEG)), a sequence of distinct regimes of hydration were observed: homogeneous distribution (∼10 Å length scales) at <13 wt.% PEG (∼1 water per EG), clusters of hydrated domains (∼50 Å radius) separated at 24 wt.% PEG (1–2 water per EG), uniformly distributed hydrated domains at 41 wt.% PEG (∼4 water per EG) and phase inversion at >50 wt.% PEG (>6 water per EG). Increasing the PEG content increased the number of these domains with only a small decrease in distance between the domains. These discrete domains appeared to coalesce to form submicron droplets at ∼60 °C, above the melting temperature of crystalline PEG. The significance of such observations on the evolution of micrometer-size channels that form during hydrolytic erosion is discussed.

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Keywords
Hydration; PEG-containing copolymers; Hydrated PEG domains; Biodegradation; Neutron scattering
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 8, Issue 4, April 2012, Pages 1459–1468
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us