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Biodegradable and photocrosslinkable polyphosphoester hydrogel

Paper ID Volume ID Publish Year Pages File Format Full-Text
12190 784 2006 8 PDF Available
Title
Biodegradable and photocrosslinkable polyphosphoester hydrogel
Abstract

A new biodegradable, photocrosslinkable and multifunctional macromer, poly(6-aminohexyl propylene phosphate) (PPE-HA)-ACRL, was synthesized by conjugation of acrylate groups to the side chains of PPE-HA. By controlling the synthetic conditions, different weight fractions of acrylate in the macromers were achieved as confirmed by 1H NMR. The hydrogels obtained from PPE-HA-ACRL through photocrosslinking were dominantly elastic. With increasing acrylate contents in the macromers, the hydrogels exhibited a lower swelling ratio and higher mechanical strength. The hydrogels with different crosslinking densities lost between 4.3% and 37.4% of their mass in 84 days when incubated in phosphate-buffered saline at 37 °C. No significant cytotoxicity of the macromers against bone marrow-derived mesenchymal stem cells from goat (GMSC) was observed at a concentration up to 10 mg/ml. Finally, GMSCs encapsulated in the photopolymerized gel maintained their viability when cultured in osteogenic medium for three weeks. Clear mineralization in the hydrogel scaffold was revealed by Von Kossa staining. This study suggests the potential of these biodegradable and photocrosslinkable as injectable tissue engineering scaffolds.

Keywords
Polyphosphoester; Photopolymerization; Hydrogel; Tissue engineering scaffold; Osteogenesis
First Page Preview
Biodegradable and photocrosslinkable polyphosphoester hydrogel
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 27, Issue 7, March 2006, Pages 1027–1034
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering