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The mechanical integrity of in vivo engineered heterotopic bone

Paper ID Volume ID Publish Year Pages File Format Full-Text
12196 784 2006 7 PDF Available
Title
The mechanical integrity of in vivo engineered heterotopic bone
Abstract

Recent advances in tissue engineering have aroused interest in growth of heterotopic bone for the repair of skeletal defects. This study demonstrates an in vivo method in minipigs of engineering individual human-sized mandible replacements of heterotopic bone with a mechanical integrity similar to natural bone.Ten individualized mandible replacement scaffolds were created using computer-aided design (CAD) techniques. Five had a resorbable external scaffold made of polylactite mesh (test group 1) and five had had a non-resorbable external scaffold of titanium mesh (test group 2). The mesh scaffolds were loaded each with five BioOss® blocks serving as internal scaffolds and 3.5 mg recombinant human Bone Morphogenetic Protein-7. The loaded mesh scaffolds were implanted into the latissimus dorsi muscles of five infant minipigs.After 6 weeks the mandible replacements were harvested. Core biopsy cylinders were taken from the replacements of both test groups and from the natural pig mandibles (control 1). Also, core biopsies from plain BioOss Blocks were gained (control 2). The core biopsy cylinders were loaded axially into a compression test device to evaluate the mechanical compression resistance. Additional specimen underwent histological examination.Both test groups resulted in successful bone induction with degrees of compression resistance [Test 1: 1.62 MPa (SD±0.73); Test 2: 1.51 MPa (SD±0.56)] statistically insignificant when compared to natural porcine mandibular bone [1.75 MPa (SD±0.69)]. This differed significantly from the much lower compression resistance seen in the unadulterated BioOss [0.92 MPa (SD±0.04)]. Following this, the in vivo engineered bone has a similar mechanical compression stability as natural bone.

Keywords
In vivo tissue engineering; BioOss; BMP 7; Bone Morphogenetic Proteins; Heterotopic bone; Mechanical stability
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 27, Issue 7, March 2006, Pages 1081–1087
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us