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The use of a bioresorbable nano-crystalline hydroxyapatite paste in acetabular bone impaction grafting

Paper ID Volume ID Publish Year Pages File Format Full-Text
12200 784 2006 9 PDF Available
Title
The use of a bioresorbable nano-crystalline hydroxyapatite paste in acetabular bone impaction grafting
Abstract

Calcium phosphates such as TCP-HA granules are considered promising bone graft substitutes. In the future, they may completely replace allograft bone for impaction grafting procedures. Mechanically, acetabular reconstructions with TCP-HA granules show high stability, however this is partly caused by excessive cement penetration, which is unfavourable from a biological perspective.It has been hypothesised that mixtures of morselised cancellous bone grafts (MCB) and/or TCP-HA granules with a nano-crystalline hydroxyapatite paste (Ostim®) may reduce cement penetration while maintaining adequate implant stability and biocompatibility of the graft mixture. To investigate this hypothesis, destructive lever-out tests and in vivo animal test were performed with various combinations of materials.Mechanically, the addition of 10% Ostim to mixtures of MCB and/or TCP-HA granules reduced cement penetration and resulted in a mechanical stability comparable to pure allograft (the current gold standard). Biologically, the application of Ostim with MCB or TCP-HA granules did not hamper the biocompatibility of the materials. Ostim was mostly osseous-integrated with MCB or TCP-HA granules after 8 weeks. Also, non-osseous-integrated Ostim remnants were observed. In tartrate resistant acid phosphatase stained sections, these few non-osseous integrated Ostim remnants were actively being resorbed by osteoclasts.In conclusion, Ostim HA-paste could be a valuable addition when TCP-HA ceramic granules are being used for acetabular bone impaction grafting procedures.

Keywords
Biocompatibility; Bone graft; Hydroxyapatite; Joint replacement; Nano-composite; Osseointegration
First Page Preview
The use of a bioresorbable nano-crystalline hydroxyapatite paste in acetabular bone impaction grafting
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 27, Issue 7, March 2006, Pages 1110–1118
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering