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Extent of iron pick-up in deforoxamine-coupled polyurethane materials for therapy of chronic wounds

Paper ID Volume ID Publish Year Pages File Format Full-Text
12220 785 2005 10 PDF Available
Title
Extent of iron pick-up in deforoxamine-coupled polyurethane materials for therapy of chronic wounds
Abstract

Polyurethane net substrates (PNS) coupled with deferoxamine (DFO) have been studied to determine the extent of Fe2+ pick-up for use in chronic wound therapy. A m solution of ferrous sulphate (FeSO4) was used to generate ferrous ions similar to those found in chronic wounds. The concentration of Fe as a function of position through the dressings was evaluated using a variety of techniques. Atomic force microscopy (AFM) and energy-filtered transmission electron microscopy (EFTEM) revealed a rough precipitated layer at the surface of activated PNS exposed to FeSO4 solution. Optical microscopy (OM) and backscattered environmental scanning electron microscopy (ESEM) showed a clear layer of Fe3+-enriched material in the surface regions exposed to DFO. The penetration depth of DFO into activated dressings was found to be 20–30 μm. Energy-dispersive X-ray (EDX) analysis was used to approximate the distribution of bound- and unbound-Fe as a function of position within BPNS and DFO-activated dressings after immersing them in a FeSO4 solution for various times. These studies have shown the activity of iron with respect to ionic state in DFO-activated PNS for potential using as dressing for chronic wounds.

Keywords
Wound dressing; Inflammation; Polyurethane; Bioactivity
First Page Preview
Extent of iron pick-up in deforoxamine-coupled polyurethane materials for therapy of chronic wounds
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 26, Issue 30, October 2005, Pages 6024–6033
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering