fulltext.study @t Gmail

Chitosan/β-lactoglobulin core–shell nanoparticles as nutraceutical carriers

Paper ID Volume ID Publish Year Pages File Format Full-Text
12222 785 2005 13 PDF Available
Title
Chitosan/β-lactoglobulin core–shell nanoparticles as nutraceutical carriers
Abstract

Chitosan (CS)/β-lactoglobulin (βlg) core–shell nanoparticles (CS-βlg nanoparticle) were successfully prepared with the aim of developing a biocompatible carrier for the oral administration of nutraceuticals. The effects of pH and initial concentrations (Cβlg) of native and denatured βlg on the properties of the nanoparticles were investigated. Uniform nanoparticles were prepared by ionic gelation with sodium tripolyphosphate (TPP). The surface charge of the particles was positive, with a zeta potential of 20–60 mV. βlg loading efficiency (LE) spanned a broad range (1–60%); and was highly sensitive to formulation pH. This adsorption can be mainly attributed to electrostatic, hydrophobic interactions and hydrogen bonding between βlg and CS. Brilliant blue (BB) release experiments showed that the nanoparticles prepared with native βlg had favorable properties to resist acid and pepsin degradation in simulated gastric conditions unlike those prepared with denatured βlg or denatured βlg crosslinked with Ca2+. When transferred to simulated intestinal conditions, the βlg shells of the nanoparticles were degraded by pancreatin.

Keywords
Chitosan; β-lactoglobulin; Nanoparticle; In vitro test
First Page Preview
Chitosan/β-lactoglobulin core–shell nanoparticles as nutraceutical carriers
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 26, Issue 30, October 2005, Pages 6041–6053
Authors
, ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us