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Effect of isothermal annealing on the hydrolytic degradation rate of poly(lactide-co-glycolide) (PLGA)

Paper ID Volume ID Publish Year Pages File Format Full-Text
12232 786 2005 7 PDF Available
Title
Effect of isothermal annealing on the hydrolytic degradation rate of poly(lactide-co-glycolide) (PLGA)
Abstract

Isothermal crystallization through annealing at 115 °C was conducted to increase the degree of crystallinity of poly (lactide-co-glycolide) (PLGA). The maximum increase in the degree of crystallinity (∼21%) was achieved after 60 min of annealing. The crystal size/perfection was observed to increase with annealing time. The annealed PLGA films were then hydrolytically degraded in phosphate buffered saline solution of pH 7.4 at 37 °C for up to 150 days. Minimal mass loss was observed throughout the time investigated, suggesting that the samples were still in the first phase of degradation. The increase in the degree of crystallinity of the PLGA samples annealed at 15 and 30 min was found to retard their overall rate of hydrolytic degradation, when compared to those samples with higher initial crystallinity (annealed for 45 and 60 min) that had faster degradation rates. The increased degradation rate at higher crystallinity was associated with the loss of amorphous material and the formation of voids during annealing, which decreases the glass transition temperature and increases the average water uptake in the samples annealed for longer times. Therefore, the increase in degree of crystallinity is found to retard hydrolytic degradation but only to a certain extent, beyond which the formation of voids through annealing increases the rate of hydrolytic degradation.

Keywords
Poly(lactide-co-glycolide); PLGA; Biodegradable; Hydrolytic degradation; Crystallinity; Isothermal annealing
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Effect of isothermal annealing on the hydrolytic degradation rate of poly(lactide-co-glycolide) (PLGA)
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 26, Issue 16, June 2005, Pages 2827–2833
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
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Price was $35.95
You save - $31
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Full-text PDF Download
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