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Nucleation of biomimetic apatite in synthetic body fluids: dense and porous scaffold development

Paper ID Volume ID Publish Year Pages File Format Full-Text
12233 786 2005 11 PDF Available
Title
Nucleation of biomimetic apatite in synthetic body fluids: dense and porous scaffold development
Abstract

The effectiveness of synthetic body fluids (SBF) as biomimetic sources to synthesize carbonated hydroxyapatite (CHA) powder similar to the biological inorganic phase, in terms of composition and microstructure, was investigated. CHA apatite powders were prepared following two widely experimented routes: (1) calcium nitrate tetrahydrate and diammonium hydrogen phosphate and (2) calcium hydroxide and ortophosphoric acid, but using SBF as synthesis medium instead of pure water. The characteristics of the as-prepared powders were compared, also with the features of apatite powders synthesized via pure water-based classical methods. The powder thermal resistance and behaviour during densification were studied together with the mechanical properties of the dense samples. The sponge impregnation process was used to prepare porous samples having morphological and mechanical characteristics suitable for bone substitution.Using this novel synthesis was it possible to prepare nanosized (≈20 nm), pure, carbonate apatite powder containing Mg, Na, K ions, with morphological and compositional features mimicking natural apatite and with improved thermal properties.After sintering at 1250 °C the carbonate-free apatite porous samples showed a surprising, high compressive strength together with a biomimetic morphology.

Keywords
Biomimetic hydroxyapatite; Carbonated hydroxyapatite; Synthetic body fluid; Powders-chemical preparation; Mechanical properties
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Nucleation of biomimetic apatite in synthetic body fluids: dense and porous scaffold development
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 26, Issue 16, June 2005, Pages 2835–2845
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us