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Recruitment of multiple cell lines by collagen-synthetic copolymer matrices in corneal regeneration

Paper ID Volume ID Publish Year Pages File Format Full-Text
12258 786 2005 12 PDF Available
Title
Recruitment of multiple cell lines by collagen-synthetic copolymer matrices in corneal regeneration
Abstract

Collagen hydrogel matrices with high optical clarity have been developed from collagen I, cross-linked with a copolymer based on N-isopropylacrylamide, acrylic acid and acryloxysuccinimide. The controlled reaction of collagen amine groups with this copolymer under neutral pH and aqueous conditions gave robust, optically clear hydrogels and prevented the excessive collagen fibrillogenesis that can lead to collagen opacity. These sterile, non-cytotoxic hydrogels allowed epithelial cell overgrowth and both stromal cell and nerve neurite ingrowth from the host tissue. This regenerative ability appeared to result from the high glucose permeability, nanoporosity and the presence of cell adhesion factors, RGD in collagen and the laminin pentapeptide, YIGSR, grafted onto the copolymer. Under physiological conditions, optical clarity superior to the human cornea and tensile performance adequate for suturing were obtained from some formulations.

Keywords
Collagen-copolymer hydrogel; Cell recruitment; Permeability; Porosity; Topography; Optical clarity
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Recruitment of multiple cell lines by collagen-synthetic copolymer matrices in corneal regeneration
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 26, Issue 16, June 2005, Pages 3093–3104
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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