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Fibrin as a cell carrier in cardiovascular tissue engineering applications

Paper ID Volume ID Publish Year Pages File Format Full-Text
12260 786 2005 9 PDF Available
Title
Fibrin as a cell carrier in cardiovascular tissue engineering applications
Abstract

In cardiovascular tissue engineering approaches, efficient seeding methods are essential. To achieve this and to save time, cells can be encapsulated in gels. Combining the advantages of a gel as a cell carrier with the advantages of a fiber-based scaffold, providing structural integrity to the developing tissue, might offer several advantages. In this study, seeding by using fibrin as a cell carrier is compared to the conventional static seeding method with regard to tissue development. Seeding with fibrin resulted in less loss of soluble collagen into the medium and a more mature extracellular matrix in a shorter period of time. The use of fibrin degradation inhibitors was shown to inhibit extracellular matrix formation, although it did not hamper cell proliferation. The use of fibrin as a cell carrier to seed cells into a fiber-based scaffold may represent a promising, timesaving approach in cardiovascular tissue engineering applications.

Keywords
Scaffold; Non-woven fabric; Fibrin; Cell encapsulation; ECM
First Page Preview
Fibrin as a cell carrier in cardiovascular tissue engineering applications
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 26, Issue 16, June 2005, Pages 3113–3121
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering