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The effect of the surface modification of titanium using a recombinant fragment of fibronectin and vitronectin on cell behavior

Paper ID Volume ID Publish Year Pages File Format Full-Text
12313 789 2005 5 PDF Available
Title
The effect of the surface modification of titanium using a recombinant fragment of fibronectin and vitronectin on cell behavior
Abstract

The surface of titanium implants is in direct contact with host tissue and plays a critical role in determining biocompatibility. Fibronectin (FN) and vitronectin (VN) are major cell adhesive proteins found in the extracellular matrix (ECM) of various tissues, and in circulating blood. The aim of this study was to evaluate the engineered biomimetic surface of titanium by using recombinant fragment of FN8–10 and VNNTD that contains the binding site for integrins. MC3T3-E1 cells seeded upon the FN8−10-coated titanium showed a marked increase in cell adhesion, proliferation, and differentiation over VNNTD-coated titanium. In addition, we confirmed that the surface properties of titanium prefer for FN8–10 over VNNTD (p<0.05) in protein adhesion. These results suggest that the FN8–10-modified titanium surface can be used to improve the osseointegration of titanium implants by enhancing bone formation.

Keywords
Titanium; Fibronectin; Protein adsorption; Dental implants; Biomimetic material
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 26, Issue 25, September 2005, Pages 5153–5157
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us