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A novel solvent system for blending of polyurethane and heparin

Paper ID Volume ID Publish Year Pages File Format Full-Text
12331 790 2003 5 PDF Available
Title
A novel solvent system for blending of polyurethane and heparin
Abstract

To improve the blood-compatibility of polyurethane, the co-solvent of tetrahydrofuran and water, a new solvent system for blending polyurethane and heparin, was proposed. After solvent casting, heparin was blended in a polyurethane film. The ATR-FTIR was used to analyze the surface chemical element and the contact angle was measured to investigate the hydrophilicity of the surface of the PUs. As the amount of heparin increased, the surface hydrophilicity was increased and all the clot times exceeded the measurement limit of the clot detection instrument when the heparin loaded on the polyurethane films was 3%, 5% and 7%. After the films were immersed in the phosphate buffered saline for 30 days, the activated partial thromboplastin time and thrombin time still exceeded the measurement limit of the clot detection instrument.

Keywords
Blood compatibility; Heparin; Blending; Polyurethane
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A novel solvent system for blending of polyurethane and heparin
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 24, Issue 22, October 2003, Pages 3915–3919
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us