fulltext.study @t Gmail

Effect of Si and Fe doping on calcium phosphate glass fibre reinforced polycaprolactone bone analogous composites

Paper ID Volume ID Publish Year Pages File Format Full-Text
1234 79 2012 11 PDF Available
Title
Effect of Si and Fe doping on calcium phosphate glass fibre reinforced polycaprolactone bone analogous composites
Abstract

Reinforcing biodegradable polymers with phosphate-based glass fibres (PGF) is of interest for bone repair and regeneration. In addition to increasing the mechanical properties, PGF can also release bioinorganics, as they are water soluble, a property that may be controllably translated into a fully degradable composite. Herein, the effect of Si and Fe on the solubility of calcium-containing phosphate-based glasses (PG) in the system (50P2O5–40CaO–(10 − x)SiO2−xFe2O3, where x = 0, 5 and 10 mol.%) were investigated. On replacing SiO2 with Fe2O3, there was an increase in the glass transition temperature and density of the PG, suggesting greater crosslinking of the phosphate chains. This significantly reduced the dissolution rates of degradation and ion release. Two PG formulations, 50P2O5–40CaO–10Fe2O3 (Fe10) and 50P2O5–40CaO–5Fe2O3–5SiO2 (Fe5Si5), were melt drawn into fibres and randomly incorporated into polycaprolactone (PCL). Initially, the flexural strength and modulus significantly increased with PGF incorporation. In deionized water, PCL–Fe5Si5 displayed a significantly greater weight loss and ion release compared with PCL–Fe10. In simulated body fluid, brushite was formed only on the surface of PCL–Fe5Si5. Dynamic mechanical analysis in phosphate buffered saline (PBS) at 37 °C revealed that the PCL–Fe10 storage modulus (E′) was unchanged up to day 7, whereas the onset of PCL–Fe5Si5E′ decrease occurred at day 4. At longer-term ageing in PBS, PCL–Fe5Si5 flexural strength and modulus decreased significantly. MC3T3-E1 preosteoblasts seeded onto PCL–PGF grew up to day 7 in culture. PGF can be used to control the properties of biodegradable composites for potential application as bone fracture fixation devices.

Keywords
Phosphate-based glass fibres; Biodegradable composites; Bioactivity; Preosteoblast; Tissue engineering
First Page Preview
Effect of Si and Fe doping on calcium phosphate glass fibre reinforced polycaprolactone bone analogous composites
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 8, Issue 4, April 2012, Pages 1616–1626
Authors
, , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us