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Bioactive glass-polymer materials for controlled release of ibuprofen

Paper ID Volume ID Publish Year Pages File Format Full-Text
12344 790 2003 7 PDF Available
Title
Bioactive glass-polymer materials for controlled release of ibuprofen
Abstract

The ibuprofen (IB) release from samples composed by SiO2–CaO–P2O5 bioactive glass, poly-L-lactic acid (PLA), and polymethylmethacrylate (PMMA) has been studied. Data showed a fast anti-inflammatory drug release during the first 8 h when these polyphasic materials are soaked in simulated body fluid (SBF). The analysis of the samples before and after different soaking periods in SBF demonstrates the growth of an apatite-like layer on the materials surface. The IB release rate is related with the growth kinetics of this layer, that is slower when the materials do not contain the biodegradable polymer PLA. On the other hand, different IB and/or glass contents do not affect the in vitro behavior of these materials.

Keywords
Drug release; Bioactive glasses; In vitro test; Polylactic acid; Polymethylmethacrylate
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 24, Issue 22, October 2003, Pages 4037–4043
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us