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Size and temperature effects on poly(lactic-co-glycolic acid) degradation and microreservoir device performance

Paper ID Volume ID Publish Year Pages File Format Full-Text
12407 791 2005 9 PDF Available
Title
Size and temperature effects on poly(lactic-co-glycolic acid) degradation and microreservoir device performance
Abstract

The component materials of controlled-release drug delivery systems are often selected based on their degradation rates. The release time of a drug from a system will strongly depend on the degradation rates of the component polymers. We have observed that some poly(lactic-co-glycolic acid) polymers (PLGA) exhibit degradation rates that depend on the size of the polymer object and the temperature of the surrounding environment. In vitro degradation studies of four different PLGA polymers showed that 150 μm thick membranes degraded more rapidly than 50 μm thick membranes, as characterized by gel permeation chromatography and mass loss measurements. Faster degradation was observed at 37 °C than 25 °C, and when the saline media was not refreshed. A biodegradable polymeric microreservoir device that we have developed relies on the degradation of polymeric membranes to deliver pulses of molecules from reservoirs on the device. Earlier molecular release was seen from devices having thicker PLGA membranes. Comparison of an in vitro release study from these devices with the degradation study suggests that reservoir membranes rupture and drug release occurs when a membrane threshold molecular weight of 5000–15000 is reached.

Keywords
Controlled drug release; Degradation; Hydrolysis; Poly(lactic acid); Poly(glycolic acid)
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Size and temperature effects on poly(lactic-co-glycolic acid) degradation and microreservoir device performance
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 26, Issue 14, May 2005, Pages 2137–2145
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us