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The use of PVP as a polymeric carrier to improve the plasma half-life of drugs

Paper ID Volume ID Publish Year Pages File Format Full-Text
12427 792 2004 8 PDF Available
Title
The use of PVP as a polymeric carrier to improve the plasma half-life of drugs
Abstract

To achieve an optimum drug delivery such as targeting or controlled release utilizing bioconjugation with polymeric modifier, the conjugate between drugs and polymeric modifiers must be designed to show desirable pharmacokinetic characteristics in vivo. In this study, we assessed the biopharmaceutical properties of various nonionic water-soluble polymers as polymeric drug carriers. Polyvinylpyrrolidone (PVP) showed the longest mean resident time (MRT) after i.v. injection of all nonionic polymers with the same molecular size. In fact, tumor necrosis factor-α (TNF-α) bioconjugated with PVP (PVP-TNF-α) circulated longer than TNF-α bioconjugated with polyethylene glycol (PEG-TNF-α) with the same molecular size. Each nonionic polymeric modifier showed a different tissue distribution. Dextran was accumulated in the spleen and liver. Polydimethylacrylamide (PDAAm) tended to distribute in the kidney. However, PVP showed the minimum volume of tissue distribution. These results suggested that PVP is the most suitable polymeric modifier for prolonging the circulation lifetime of a drug and localizing the conjugated drug in blood.

Keywords
Polyethylene glycol (PEG); Polyvinylpyrrolidone (PVP); Bioconjugation; Tumor necrosis factor-alpha (TNF-α); Polymeric modifier
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The use of PVP as a polymeric carrier to improve the plasma half-life of drugs
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 25, Issue 16, July 2004, Pages 3259–3266
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us