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In situ polymerizable polyethyleneglycol containing polyesterpolyol acrylates for tissue sealant applications

Paper ID Volume ID Publish Year Pages File Format Full-Text
12430 792 2004 9 PDF Available
Title
In situ polymerizable polyethyleneglycol containing polyesterpolyol acrylates for tissue sealant applications
Abstract

Polyesterpolyol macromers were prepared with succinic acid and polyethylene glycols (PEG) of different molecular weights. The resulting polyols were acrylated to render them photo-cross-linkable. They could be very rapidly cross-linked into non-tacky films with long-wavelength UV radiation. The resulting products were characterized by gel content, water equilibrium swell, cross-link density, Tg, tensile strength, degradation and in vitro burst strengths. Though all of them formed transparent contact lens like films, increasing the PEG molecular weight has resulted in polymers with higher hydrophilicity resulting in higher swelling, faster degradation, higher tensile strength, elongation at break and burst strength. Addition of vinyl pyrrolidinone as a reactive diluent has increased the mechanical as well as burst strength of the polymer. In vitro release of sulfamethoxazole entrapped in these cross-linked matrices was also studied.

Keywords
Photopolymerization; Cross-linking; Polyethyleneoxide; Tissue sealant; Burst test; Degradation
First Page Preview
In situ polymerizable polyethyleneglycol containing polyesterpolyol acrylates for tissue sealant applications
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 25, Issue 16, July 2004, Pages 3283–3291
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering