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In vitro evaluation of low-intensity pulsed ultrasound in herniated disc resorption

Paper ID Volume ID Publish Year Pages File Format Full-Text
12467 793 2005 11 PDF Available
Title
In vitro evaluation of low-intensity pulsed ultrasound in herniated disc resorption
Abstract

Herniated disc (HD) is often resolved spontaneously without surgical intervention. HD resorption (HDR) is associated with abundant vascularization and infiltration of macrophages (Mφ) into the intervertebral disc (ID), as well as with high levels of matrix metalloproteinases (MMPs). Low-intensity pulsed ultrasound (LIPUS) accelerates bone fracture healing in clinical studies, and angiogenic factors are involved in the mechanism of action. In the present study, we examined the effects of LIPUS on HDR in a rat in vitro HD model. HDR was enhanced by LIPUS as measured by the change in the wet weight of the cultured ID. The secretion of tumor necrosis factor-α (TNF-α) and macrophage chemoattractant protein-1 (MCP-1) from Mφ into the culture medium was stimulated by LIPUS. LIPUS also enhanced matrix metalloproteinase-3 (MMP-3) maturation. Moreover, many apoptotic cell death were observed in the HDR groups with LIPUS exposure. These results suggest that LIPUS enhanced the HDR via MMP-3 activation through TNF-α and MCP-1 pathways. Although animal studies and clinical trial are needed to understand the LIPUS effects on HDR, LIPUS treatment might be an effective treatment for accelerating HDR.

Keywords
In vitro test; Intervertebral disc; Macrophage; Matrix metalloproteinase; Spinal surgery; Low-intensity pulsed ultrasoundID, intervertebral disc; AF, annulus fibrosus; NP, nucleus pulposus; HD, herniated disc; Mφ, macrophages; HDR, herniated disc resorpti
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In vitro evaluation of low-intensity pulsed ultrasound in herniated disc resorption
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 26, Issue 34, December 2005, Pages 7104–7114
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us