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Compositional changes of a dicalcium phosphate dihydrate cement after implantation in sheep

Paper ID Volume ID Publish Year Pages File Format Full-Text
12518 795 2003 12 PDF Available
Title
Compositional changes of a dicalcium phosphate dihydrate cement after implantation in sheep
Abstract

A hydraulic calcium phosphate cement having dicalcium phosphate dihydrate (DCPD) as end-product of the setting reaction was implanted in a cylindrical defect in the diaphysis of sheep for up to 6 months. The composition of the cement was investigated as a function of time. After setting, the cement composition consisted essentially of a mixture of DCPD and β-tricalcium phosphate (β-TCP). In the first few weeks of implantation, the edges of the cement samples became depleted in DCPD, suggesting a selective dissolution of DCPD, possibly due to low pH conditions. The cement resorption at this stage was high. After 8 weeks, the resorption rate slowed down. Simultaneously, a change of the color and density of the cement center was observed. These changes were due to the conversion of DCPD into a poorly crystalline apatite. Precipitation started after 6–8 weeks and progressed rapidly. At 9 weeks, the colored central zone reached its maximal size. The fraction of β-TCP in the cement was constant at all time. Therefore, this study demonstrates that the resorption rate of DCPD cement is more pronounced as long as DCPD is not transformed in vivo.

Keywords
Brushite; Cement; In vivo test; Apatite
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Compositional changes of a dicalcium phosphate dihydrate cement after implantation in sheep
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 24, Issue 20, September 2003, Pages 3463–3474
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us