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Synthesis, permeability and biocompatibility of tricomponent membranes containing polyethylene glycol, polydimethylsiloxane and polypentamethylcyclopentasiloxane domains ☆

Paper ID Volume ID Publish Year Pages File Format Full-Text
12521 795 2003 11 PDF Available
Title
Synthesis, permeability and biocompatibility of tricomponent membranes containing polyethylene glycol, polydimethylsiloxane and polypentamethylcyclopentasiloxane domains ☆
Abstract

The synthesis of “smart” tricomponent amphiphilic membranes containing poly(ethylene glycol) (PEG), polydimethylsiloxane (PDMS) and polypentamethylcyclopentasiloxane (PD5) domains is described. Contact angle hysteresis indicates that in air, the surfaces of such PEG/PD5/PDMS membranes are enriched by the hydrophobic components, PDMS and PD5, while in water, the surfaces are rich in the hydrophilic PEG. The oxygen permeability of a series of membranes with varying Mc,hydrophilic (Mn,PEG=4600, 10,000 and 20,000 g/mol) and varying PEG/PD5/PDMS compositions was studied. Oxygen permeability increased with the amount of PDMS in the membrane. The molecular weight cut-off (MWCO) ranges and permeability coefficients of insulin through a series of PEG/PD5/PDMS(=29/14/57) membranes with varying Mc,hydrophilic were determined. Insulin permeability is directly related to Mc,hydrophilic of the membrane. MWCO studies show that the membranes are semipermeable to, i.e., allow the transport of smaller proteins such as insulin (Mn=5733 g/mol, Rs=1.34 nm) and cytochrome c (Mn=12,400 g/mol, Rs=1.63 nm), but are barriers to larger proteins such as albumin (Mn=66,000 g/mol, Rs=3.62 nm). Implantation of representative membranes in rats showed them to be biocompatible. According to these studies, PEG/PD5/PDMS membranes may be suitable for biological applications, e.g., immunoisolation of cells.

Keywords
Membrane; Oxygen diffusion; Insulin diffusion; Hydrogels; Biocompatibility; Molecular weight cut-off
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Synthesis, permeability and biocompatibility of tricomponent membranes containing polyethylene glycol, polydimethylsiloxane and polypentamethylcyclopentasiloxane domains ☆
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 24, Issue 20, September 2003, Pages 3493–3503
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us