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Promotion of bone formation by simvastatin in polyethylene particle-induced osteolysis ☆

Paper ID Volume ID Publish Year Pages File Format Full-Text
12541 799 2005 7 PDF Available
Title
Promotion of bone formation by simvastatin in polyethylene particle-induced osteolysis ☆
Abstract

The effects of statins on bone formation in periprosthetic osteolysis have not been determined to date. We investigated the effect of the HMG-CoA reductase inhibitor simvastatin on osteoblastic bone formation under conditions of ultra-high molecular weight polyethylene (UHMWPE) particle-induced osteolysis.The murine calvarial osteolysis model was utilized in 21 C57BL/J6 mice randomized to three groups. Group I underwent sham surgery only, group II received UHMWPE particles, and group III, particles and simvastatin treatment. After 2 weeks, calvaria were processed for histomorphometry and stained with Giemsa dye. New bone formation was measured as osteoid tissue area within the midline suture. Bone thickness was quantified as indicator of net bone growth. Statistical analysis was performed using one-way ANOVA and a Student's t-test.New bone formation and bone thickness were significantly enhanced following simvastatin treatment. New bone formation was 0.008±0.008 mm2 in sham controls (group I), 0.015±0.012 mm2 after particle implantation without further intervention (group II), compared to 0.083±0.021 mm2 with particle implantation and simvastatin treatment (group III) (p=0.003)(p=0.003). The bone thickness was 0.213±0.007 mm in group I, 0.183±0.005 mm in group II, and 0.238±0.009 mm in group III (p=0.00008)(p=0.00008).In conclusion, simvastatin treatment markedly promoted bone formation and net bone growth in UHMWPE particle-induced osteolysis in a murine calvarial model. These new findings indicate that simvastatin may have favorable osteoanabolic effects on wear debris-mediated osteolysis after total joint arthroplasty, involving local stimulation of osteoblastic bone formation.

Keywords
Osteolysis; Wear debris; Polyethylene; Calvarium; Osteoblast
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Promotion of bone formation by simvastatin in polyethylene particle-induced osteolysis ☆
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 26, Issue 29, October 2005, Pages 5783–5789
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us