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The effects of particle size and surface coating on the cytotoxicity of nickel ferrite

Paper ID Volume ID Publish Year Pages File Format Full-Text
12545 799 2005 9 PDF Available
Title
The effects of particle size and surface coating on the cytotoxicity of nickel ferrite
Abstract

The safety and toxicity of nanoparticles are of growing concern despite their significant scientific interests and promising potentials in many applications. The properties of nanoparticles depend not only on the size but also the structure, microstructure and surface coating. These in turn are controlled by the synthesis and processing conditions. The dependence of cytotoxicity on particle size and on the presence of oleic acid as surfactant on nickel ferrite particles were investigated in vitro using the Neuro-2A cell line as a model. For nickel ferrite particles without oleic acid prepared by ball milling, cytotoxicity was independent of particle size within the given mass concentrations and surface areas accessible to the cells. For nickel ferrite particles coated with oleic acid prepared by the polyol method, the cytotoxicity significantly increased when one or two layers of oleic acid were deposited. Large particles (150±50 nm diameter) showed a higher cytotoxicity than smaller particles (10±3 nm diameter).

Keywords
Cytotoxicity; Surface treatment; Particle size; Magnetic nanoparticles
First Page Preview
The effects of particle size and surface coating on the cytotoxicity of nickel ferrite
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 26, Issue 29, October 2005, Pages 5818–5826
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering