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Fabrication of viable tissue-engineered constructs with 3D cell-assembly technique

Paper ID Volume ID Publish Year Pages File Format Full-Text
12550 799 2005 8 PDF Available
Title
Fabrication of viable tissue-engineered constructs with 3D cell-assembly technique
Abstract

We have recently developed an organ manufacturing technique that enables us to form cell/biomaterial complex three-dimensional (3D) architectures in designed patterns. This technique employs a highly accurate 3D micropositioning system with a pressue-controlled syringe to deposit cell/biomaterial structures with a lateral resolution of 10 μm. The pressure-activated micro-syringe is equipped with a fine-bore exit needle using which a wide variety of 3D patterns with different arrays of channels (through-holes) were created. The channels can supply living cells with nutrients and allow removing the cell metabolites. The embedded cells remain viable and perform biological functions as long as the 3D structures are retained. The new technology has the potential for eventual high-throughput production of artificial human tissues and organs.

Keywords
Cell assembling; Rapid prototyping; Three-dimensional precursor; Implantable bioartificial organs; Hydrogel
First Page Preview
Fabrication of viable tissue-engineered constructs with 3D cell-assembly technique
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 26, Issue 29, October 2005, Pages 5864–5871
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering