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Hemocompatibility of titanium oxide films

Paper ID Volume ID Publish Year Pages File Format Full-Text
12564 800 2003 11 PDF Available
Title
Hemocompatibility of titanium oxide films
Abstract

Hemocompatibility is a key property of biomaterials that come in contact with blood. Surface modification has shown great potential for improving the hemocompatibility of biomedical materials and devices. In this paper, we describe our work of improving hemocompatibility with Ti–O thin films prepared by plasma immersion ion implantation and deposition and by sputtering. The structure and surface chemical and physical properties of the films were characterized by X-ray diffraction, Auger electron spectroscopy, atomic force microscopy (AFM), contact angle measurement, and Hall effect measurement. The behavior of fibrinogen adsorption was investigated by 125I radioactive isotope labeling and AFM. Systematic evaluation of hemocompatibility, including in vitro clotting time, thrombin time, prethrombin time, platelet adhesion, and in vivo implantation into dog's ventral aorta or right auricle from 17 to 90 days, proved that Ti–O films have excellent hemocompatibility. It is suggested that the significantly lower interface tension between Ti–O films and blood and plasma proteins and the semiconducting nature of Ti–O films give them their improved hemocompatibility.

Keywords
Titanium oxide film; Hemocompatibility; Interface tension; N-type semiconductor
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 24, Issue 13, June 2003, Pages 2177–2187
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
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